MyBioSource.com's ASXL1 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, and Western Blot. The ASXL1 Antibody (Center) was generated using ASXL1 as the antigen and it reacts with Human, and Mouse.
Description
This gene is similar to the Drosophila additional sex
combs gene, which encodes a chromatin-binding protein required for
normal determination of segment identity in the developing embryo.
The protein is a member of the Polycomb group of proteins, which
are necessary for the maintenance of stable repression of homeotic
and other loci. The protein is thought to disrupt chromatin in
localized areas, enhancing transcription of certain genes while
repressing the transcription of other genes. The protein encoded by
this gene functions as a ligand-dependent co-activator for retinoic
acid receptor in cooperation with nuclear receptor coactivator 1.
Mutations in this gene are associated with myelodysplastic
syndromes and chronic myelomonocytic leukemia. Alternative splicing
results in multiple transcript variants